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Correspondence: M Pasparakis, Institute for Genetics, Center for Molecular Medicine (CMMC), Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Joseph-Stelzmann-Strasse 26, Cologne D-50931, Germany.
The cartoon employs an eye-assaulting color scheme not generally seen since the days of “Physical” by Olivia Newton-John.
It is puzzling, however, how the cartoon characters in this little movie expect to do well at Bang Fit, since they seem to lack genitalia.
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As passive viewers enjoy watching various bangs, they may be neglecting their physical well-being.
The Pornhub team apologizes for that, and is atoning by creating Bang Fit, “a game-based fitness program” that will get you “into incredible shape while having the time of your life.” Essentially, this is an online game that invites players to strap smartphones to their bodies as they copulate in order to score points and burn calories.
The program is being introduced with a colorful animated video that manages to evoke both the 1970s porn craze and the 1980s fitness craze.
TNF deficiency in all cells or conditional LPC-specific ablation of TNFR1, Fas or TRAIL-R did not prevent hepatocyte apoptosis, hepatitis and HCC development in NEMO mice with combined LPC-specific deficiency of TNFR1, Fas and TRAIL-R and found that also simultaneous lack of all three death receptors did not prevent hepatocyte apoptosis, chronic hepatitis and HCC development.
However, LPC-specific combined deficiency in TNFR1, Fas and TRAIL-R protected the NEMO-deficient liver from LPS-induced liver failure, showing that different mechanisms trigger spontaneous and LPS-induced hepatocyte apoptosis in NEMO mice crossed into a RAG-1-deficient genetic background-developed hepatitis and HCC.